Background: Primary fallopian tube carcinoma (PFTC) is a rare and poorly studied disease. Given its low incidence and evolving diagnostic classification, population-based data are essential to improve understanding of its prognostic determinants. This study aims to identify the clinical prognostic factors of patients with PFTC. Materials and Methods: Patients diagnosed with PFTC between 2010 and 2015 were selected from the Surveillance, Epidemiology, and End Results database. Univariate and multivariate Cox regression analyses were conducted to identify independent prognostic factors. Based on these factors, prognostic nomograms were developed to estimate 3- and 5-year overall survival (OS) and cancer-specific survival at the population level. Results: A total of 1241 patients were randomly assigned to the training cohort ( n = 869) and the test group ( n = 372). In the multivariate Cox regression, age (22–56, 57–71 and 72–92), race (White, Black, and Other), the International Federation of Gynecology and Obstetrics (FIGO) staging (I, II, III, and IV), and laterality (lateral and bilateral) were identified as independent prognostic factors for patients with PFTC. Finally, nomograms consisting of age, race, FIGO stage, surgery type, and lymphadenectomy were constructed. The area under the time-dependent receiver operating characteristic curve values for the 3-year/5-year OS were 0.730/0.750 in the training cohort and 0.726/0.803 in the test cohort. Conclusions: Nomograms derived from a large population-based cohort provide prognostic insight and risk stratification for patients with PFTC within a defined historical context. The identified prognostic factors serve as a reference for studies and warrant validation in contemporary cohorts and clinical trials.
Chen et al. (Sun,) studied this question.