What question did this study set out to answer?

This research aims to understand how pseudorabies virus impacts the placenta and influences maternal-infant transmission.

March 26, 2026Open Access

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Pathogenesis of pseudorabies virus in mouse placenta: insights into maternal–infant transmission mechanisms

Key Points

This research aims to understand how pseudorabies virus impacts the placenta and influences maternal-infant transmission.
Analyzed the effects of maternal viremia on placenta.
Examined viral replication locations within the placenta.
Investigated the relationship between PRV infection and pregnancy outcomes.
Pseudorabies virus disrupts the barrier function of the placenta.
Viral replication occurs primarily in decidual and labyrinthine regions.
Infection can lead to pregnancy failure due to inflammation.

Abstract

Pseudorabies virus can be transmitted vertically by disrupting the barrier function of the placenta. Maternal viremia drives preferential PRV replication within the placenta. PRV preferentially colonizes decidual and labyrinthine placental regions. PRV can cause pregnancy failure via inflammation.

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Cite This Study

Li et al. (Tue,) studied this question.

synapsesocial.com/papers/69c4cd05fdc3bde448918dd1 https://doi.org/https://doi.org/10.1128/spectrum.03648-25

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