Adipose tissue microvascular is linked to insulin resistance and lipidome alterations in treated HIV

Key Points

• To explore the relationship between adipose tissue microvascular remodeling and metabolic health in people with HIV on ART.
• Analyzed adipose tissue microvasculature in people with HIV on contemporary ART.
• Evaluated plasma lipid species associated with insulin resistance.
• Assessed interventions for endothelial dysfunction targeting.
• Adipose tissue changes correlated strongly with insulin resistance.
• Alterations in lipid species were observed in treated individuals.
• Potential interventions could enhance metabolic health in this population.