Parameters regulation and mechanical properties prediction of two photon printed hydrogels based on chemo-mechanical coupling model

Key Points

• To establish a systematic relationship between printing parameters and the mechanical properties of hydrogels during two photon polymerization.
• Analyzed radical polymerization kinetics of thermosensitive N-isopropylacrylamide hydrogels.
• Developed a chemo-mechanical coupling model for two photon processing.
• Conducted experiments to characterize the relationship between monomer conversion rates and mechanical properties.
• Quantitative predictions of monomer conversion rates based on key printing parameters.
• Identified an exponential relationship between monomer conversion and the macroscopic mechanical properties of hydrogels.
• Established a predictive model linking printing conditions to mechanical performance.