Peptidome profiling in heart failure patients identified bioactive peptides related to the renin-angiotensin system, natriuretic peptides, and cardiometabolic regulation compared to non-HF controls.
Case-Control
This study maps the heart failure peptidome, identifying key bioactive peptides that complement existing protein-based biomarkers and provide a resource for future exploration.
This study uniquely identifies peptides according to their regulation and likelihood of being a bioactive peptide in patients with HF compared with non-HF controls. The study provides crucial peptide-level information to complement protein-based methodologies. The most promising peptides were related to the renin-angiotensin system, natriuretic peptides, and cardiometabolic regulation. The stepwise ranking highlights the HF peptide signal important for outcome and provides a rich resource for additional exploration.
Madsen et al. (Tue,) conducted a case-control in Heart Failure. Peptidome profiling vs. Non-HF controls was evaluated on Peptide regulation and likelihood of being a bioactive peptide. Peptidome profiling in heart failure patients identified bioactive peptides related to the renin-angiotensin system, natriuretic peptides, and cardiometabolic regulation compared to non-HF controls.