What question did this study set out to answer?

This research aims to explore how RCN3 influences the differentiation of monocytes into macrophages during sepsis.

March 26, 2026Open Access

Effect of reticulocalbin 3 on monocyte-to-macrophage differentiation in sepsis through modulating autophagy

DZDanni ZanCapital Medical University ZXZhuo XuTsinghua University FDFangping DingCapital Medical University

Key Points

This research aims to explore how RCN3 influences the differentiation of monocytes into macrophages during sepsis.
Analyzed the expression of RCN3 in monocytes from septic conditions.
Investigated the role of RCN3 in modulating autophagy.
Examined the effects on differentiation pathways leading to macrophage formation.
Increased levels of RCN3 were found in septic monocytes.
RCN3 upregulation positively influenced the differentiation process into macrophages.
Modulation of autophagy was identified as a mechanism through which RCN3 exerts its effects.

Abstract

The upregulation of RCN3 in sepsis facilitates monocyte-to-macrophage differentiation by modulating autophagy. These findings also suggest that RCN3 in circulating monocytes presents a potential therapeutic target for sepsis.

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