What question did this study set out to answer?

This report aims to explore the association between rapidly progressive IgA nephropathy and a history of breast cancer.

March 27, 2026Open Access

Wcn26-2298 Rapidly Progressive Iga Nephropathy in a Patient With a History of Breast Cancer: A Case Report and Literature Review

Key Points

This report aims to explore the association between rapidly progressive IgA nephropathy and a history of breast cancer.
Detailed case report of a patient with rapidly progressive IgA nephropathy and breast cancer history.
Review of existing literature on the relationship between IgAN and malignancy.
The patient developed an uncommon crescentic variant of IgA nephropathy.
There is a potential link between the patient's malignancy and the onset of rapidly progressive renal failure.
Early identification of glomerular disease in oncology patients may enhance treatment outcomes.

Abstract

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and usually follows a slow, chronic course. However, in rare cases, an extracapillary or crescentic variant may develop, leading to rapidly progressive renal failure. The coexistence of IgAN with malignancy, particularly breast cancer, is exceptionally uncommon but may suggest a paraneoplastic or immune-mediated link. Understanding such associations is clinically relevant, as early recognition of atypical glomerular presentations in oncology patients may improve outcomes.

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