hypertension differed by APOL1 status (no risk 24%, low risk 36%, high risk 44%; p=0.047).Pre-eclampsia complications did not differ between the groups (HELLP p=0.747; abruptio p=0.737; eclampsia p=0.926).PrAKI occurred in 110/217 (51%) no-risk, 25/59 (42%) lowrisk, and 8/18 (44%) high-risk groups (p=0.492).At 3 months, proportions with eGFR <90 mL/min/1.73m 2 (no risk 19%, low risk 30%, high risk 29%; p=0.185) and persistent albuminuria (49%, 41%, 35%; p=0.353) were similar.However, women with any APOL1 risk allele (mono-or biallelic) had a lower mean eGFR within CKD stage 1 (p=0.030),suggesting early subclinical impact (Figure 1). Conclusion:In this Cape Town cohort with complicated pre-eclampsia, APOL1 risk variants were not associated with PrAKI.Nonetheless, carriers exhibited lower eGFR within stage 1 CKD at 3 months, indicating potential early vulnerability.These findings support postpartum kidney surveillance, irrespective of APOL1 status, and longer followup and mechanistic studies in African populations.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Peterni Coloyan (Wed,) studied this question.