The abstract is truncated and does not report the results of aldosterone administration on MR activation-induced hemodynamic changes in male Sprague-Dawley rats.
Does the severity of the initial eGFR dip after canagliflozin administration predict long-term renoprotective effects in patients with diabetic kidney disease?
A more severe initial eGFR dip following canagliflozin initiation in patients with diabetic kidney disease is a good prognostic marker that predicts a milder long-term decline in renal function.
Introduction:The non-steroidal selective mineralocorticoid receptor blocker (nsMRB) finerenone has demonstrated renoprotective effects in patients with type 2 diabetes and chronic kidney disease (CKD) (FIDELIO-DKD study).Similarly, the nsMRB esaxerenone (Esax) significantly reduced albuminuria compared with placebo in a phase III trial involving early diabetic kidney disease (DKD), suggesting renoprotective effects comparable to finerenone (ESAX-DN study).However, the molecular mechanisms underlying the renoprotective and albuminuria-lowering effects of nsMRBs remain unclear.After nsMRB administration, a transient decline in estimated glomerular filtration rate (eGFR) is observed, followed by recovery upon withdrawal, similar to SGLT2 inhibitors.This indicates that MR activity functionally regulates GFR and may contribute to glomerular hyperfiltration in DKD.Few studies, however, have directly examined the link between MR activity and glomerular hemodynamics.The macula densa (MD) plays a central role in tubuloglomerular feedback (TGF).MR activation in MD cells is thought to attenuate TGF through nitric oxide (NO), though mechanisms are not fully defined.We hypothesized that MR activation in MD cells contributes to glomerular hyperfiltration in DKD and investigated this using in vivo imaging and a newly established MD cell line (MDgeo).Methods: To assess MR activation-induced hemodynamic changes, male Sprague-Dawley rats (8-10 weeks, n = 3-4) received aldosterone
Kato et al. (Wed,) conducted a other in Diabetic kidney disease. Aldosterone was evaluated on Hemodynamic changes. The abstract is truncated and does not report the results of aldosterone administration on MR activation-induced hemodynamic changes in male Sprague-Dawley rats.