What question did this study set out to answer?

To examine the effectiveness of calcimimetics versus bisphosphonates in treating primary hyperparathyroidism.

March 28, 2026Open Access

Wcn26-8022 a Case of Primary Hyperparathyroidism in Which Calcimimetics Was Ineffective but Bisphosphonate Alone Was Effective

Key Points

To examine the effectiveness of calcimimetics versus bisphosphonates in treating primary hyperparathyroidism.
Case report of a single patient with primary hyperparathyroidism
Assessment of electrolyte levels including calcium, magnesium, and potassium
Monitoring treatment outcomes with calcimimetics and bisphosphonates
Calcimimetics did not correct electrolyte imbalances or symptoms
Bisphosphonate treatment led to significant improvement
Notable electrolyte imbalances included hypokalemia and hypomagnesemia

Abstract

hypokalemia 2.70 mmol/L (SD 0.44), hypomagnesemia 0.47 mmol/L (SD 0.12), hypocalcemia 1.98 mmol/L (SD 0.14), hyponatremia 127 mmol/L (SD 4.84). Conclusion:In conclusion, this study shows the high incidence of AKI and electrolyte imbalances among patients treated with Polymyxin B, with the most frequent electrolyte abnormality being hypomagnesemia and hypokalemia.While the cumulative dose and duration of polymyxin, and the presence of multiple sites of infection and use of vancomycin had a statistically significant increased incidence of nephrotoxicity, none of the factors analyzed were shown to be independent risk factors for the occurrence of nephrotoxicity.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

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Cite This Study

Tomida et al. (Wed,) studied this question.

synapsesocial.com/papers/69c770c08bbfbc51511e0b80 https://doi.org/https://doi.org/10.1016/j.ekir.2026.103849

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