Preservation of adaptive immunity after nonmyeloablative hematopoietic cell transplantation in adults with sickle cell disease (PROTECT study)

Key Points

• This research aims to evaluate the preservation of adaptive immunity in adults with sickle cell disease following nonmyeloablative hematopoietic cell transplantation.
• Conducted in adults with sickle cell disease
• Utilized nonmyeloablative hematopoietic cell transplantation
• Assessed adaptive immune responses post-transplant
• Adaptive immunity was preserved in the majority of participants after transplantation
• Immune system function showed a positive correlation with graft health
• Minimal complications were observed in the post-transplant recovery