Association between pharmacological tenofovir adherence measures and subsequent 24-week viral load outcomes for people with HIV in South Africa | Synapse
The aim is to examine the relationship between tenofovir adherence measures and 24-week viral load outcomes in people living with HIV.
Assessed DBS TFV-DP levels to evaluate adherence.
Analyzed POC urine TFV to determine recent ART initiation and viraemia.
Measured viral load and CD4 count after 24 weeks.
Higher DBS TFV-DP levels correlated with undetectable viraemia at 24 weeks.
Undetectable POC urine TFV linked to recent ART initiation and current viraemia.
Lower CD4 counts observed in those with detectable viraemia.
Abstract
DBS TFV-DP was associated with viraemia at 24-weeks and could help predict future viraemia. Undetectable POC urine TFV was associated with recent ART initiation, current viraemia, and lower CD4 count.