Abstract The management of complex bite wounds, particularly in patients with comorbidities, presents a significant clinical challenge due to the high risk of infection and prolonged healing times. This case report highlights the successful use of intact fish skin grafts as a novel treatment modality for a primary contaminated bite wound at the patient with comorbidities such as diabetes mellitus and rheumatoid artritis with cortisone use. A 54-year-old European female patient with a medical history of rheumatoid arthritis and type 2 diabetes mellitus presented with a large, full-thickness dog bite wound on her right lower leg. Surgical debridement and broad-spectrum antibiotic administration, an intact Kerecis fish skin graft was applied and secured. The application of an intact fish skin xenograft, combined with surgical debridement and appropriate antibiotic therapy, proved to be a highly effective treatment for a complex bite wound in an immunocompromised patient.
Adamovic et al. (Sun,) studied this question.