What question did this study set out to answer?

The aim is to evaluate the influence of chitosan in bone regenerative biomaterials through systematic literature review.

March 28, 2026Open Access

Influence of chitosan in bone regenerative biomaterials – A systematic review

Key Points

The aim is to evaluate the influence of chitosan in bone regenerative biomaterials through systematic literature review.
Conducted extensive literature review using Medline/PubMed and Cochrane databases.
Included in-vivo studies and followed PICO framework for inclusion criteria.
Reviewed 53 articles that met predefined inclusion criteria.
Chitosan composites showed enhanced mineralization and bone formation in various animal models.
Utilized delivery systems included sponges, hydrogels, aerogels, microspheres, and composites.
Incorporation of biologics further improved regenerative outcomes.

Abstract

Background: Chitosan is promising for bone regeneration due to biocompatibility, biodegradability and antimicrobial activity. Methods: Extensive literature review (Medline/PubMed, Cochrane) using PICO; in-vivo studies included. 53 articles met inclusion. Results: Studies used various animal models and chitosan composites with TCP/β-TCP, hydroxyapatite, xenografts, growth factors and stem cells. Delivery systems included sponges, hydrogels, aerogels, microspheres and composites. Chitosan composites enhanced mineralization and bone formation. Conclusion: Chitosan scaffolds and composites demonstrate efficacy in promoting in-vivo bone regeneration; incorporation of biologics further enhances outcomes.

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Reetika Gaddale (Sun,) studied this question.

synapsesocial.com/papers/69c771dd8bbfbc51511e1f4d https://doi.org/https://doi.org/10.4103/ijdr_202637s1_abs_59

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