Objective: This study aimed to investigate the features of eight patients diagnosed with primary gastrointestinal system lymphoma.Materials and Methods: The features of patients diagnosed with primary gastrointestinal system lymphoma between 2021 and 2024 at the İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology, were retrospectively investigated.Results: Of the eight patients, 5 (62.5%) were male. The mean age was 55.1±18.8 (28–70) years. 4 (50%) patients had diabetes mellitus, one had Crohn's disease, one had decompensated cirrhosis, and one had compensated cirrhosis. The most common complaint of patients was stomachache. One of the patients who presented with stomachache had volvulus, one had ascites infection, and one had acute pancreatitis. Intestinal T-cell lymphoma was diagnosed in two, Burkitt lymphoma (BL) in two, Hodgkin lymphoma in one, mantle cell lymphoma (MCL) in one, follicular lymphoma in one and B-cell non-Hodgkin's lymphoma in one patients. The diagnosis of 4 (50%) patients was made by surgical resection, 3 (37.5%) patients were diagnosed by endoscopic biopsy and 1 (12.5%) patient was computerized by ascites fluid cytological examination and endoscopic biopsy. Four patients had lymphoma involvement in the small intestine, one patient had stomach, one patient had stomach and small intestine, one patient had spleen, and one patient had stomach, small intestine, and pancreas involvement.Conclusion: Primary gastrointestinal system lymphomas are rare diseases that can present in a wide age range and very different clinical presentations, and the small intestine was the most common involvement site in our cohort.
İstemihan et al. (Mon,) studied this question.