Metal Triflimide-Mediated Acylation of Sulfonamides and Transacylation of N-Acylsulfonamides †

Key Points

• This research aims to present a new method for acylation of sulfonamides and their transacylation derivatives.
• Developed a novel method using Cu(NTf2)2 as a catalyst.
• Utilized carboxylic anhydrides and acyl chlorides for acylation process.
• Conducted reaction at 0.1 mol% concentration of the catalyst.
• Acylation of sulfonamides occurred smoothly with the new method.
• Transacylation of N-acylsulfonamides was successfully achieved.
• The efficiency of the reaction indicates potential for broader applications in organic synthesis.