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This research aims to investigate how long-term high-altitude exposure affects metabolic profiles in populations living at sea level.

March 29, 2026Open Access

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Metabolic Landscape in Response to Long-term High-Altitude Exposure

Key Points

This research aims to investigate how long-term high-altitude exposure affects metabolic profiles in populations living at sea level.
Utilized UHPLC-MS/MS technology for analysis.
Analyzed plasma metabolomic profiles of a single cohort.
Compared profiles under plain conditions and after high-altitude exposure.
Identified distinct metabolic remodeling patterns following high-altitude adaptation.
Showed significant variations in metabolomic profiles indicative of physiological adjustments.

Abstract

This study employed UHPLC-MS/MS technology to analyze plasma metabolomic profiles of the same cohort under plain conditions and after long-term high-altitude exposure, systematically elucidating the metabolic remodeling patterns in plain-dwelling populations following long-term high-altitude adaptation.

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王加琪(Jiaqi Wang) (Thu,) studied this question.

synapsesocial.com/papers/69c8c277de0f0f753b39cc69 https://doi.org/https://doi.org/10.26036/cnp0007256

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Metabolic Landscape in Response to Long-term High-Altitude Exposure

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Abstract

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