Fibroblasts are mesenchymal cells which physiologically possess numerous functions and belong to basic cellular components necessary to maintain tissue homeostasis and are essential for extracellular matrix formation and maintenance. In addition, fibroblasts are of paramount importance in regeneration and wound healing as they interact with the immune system. These unique properties determine their great utility in cell therapies in the field of regenerative medicine. This review summarizes the mechanisms of action and clinical applications of fibroblast-based therapies as well as highlighting the future perspectives including the use of allogeneic cells.
Bihuniak et al. (Mon,) studied this question.