Brain network communication model reveals diffusion‐based structure–function decoupling in mild cognitive impairment

Key Points

• The research aims to investigate the relationship between brain network communication and structure-function decoupling in mild cognitive impairment (MCI).
• Analyzed brain network communication using diffusion-based models.
• Assessed the impact of white matter hyperintensities (WMH) on brain function and structure.
• Introduced a novel framework for evaluating lesion effects.
• Identified significant diffusion-based structure-function decoupling in individuals with MCI.
• Provided insights into alterations in brain network dynamics due to white matter injury.