Enantioselective synthesis of chiral organoborons via carbene B-H insertion catalyzed by engineered neuroglobin

Key Points

• The aim is to create chiral organoboron compounds using engineered neuroglobin for improved enantioselectivity.
• Engineered neuroglobin was used as a catalyst.
• Carbene B-H insertion reactions were performed to synthesize organoboron compounds.
• Yields and enantioselectivity were measured and analyzed.
• Chiral organoboron compounds were produced with yields up to 66%.
• Achieved an enantiomeric ratio of 97:3.
• Demonstrated the effectiveness of the engineered neuroglobin in catalysis.