Aloperine ameliorates cisplatin-induced acute kidney injury by inhibiting the cGAS-STING pathway

Key Points

• This research aims to clarify how aloperine exerts kidney protective effects through the cGAS-STING pathway.
• Utilized male C57 mice with acute kidney injury induced by cisplatin injection.
• Divided mice into control, model, and aloperine treatment groups.
• Evaluated kidney damage through histological scoring, flow cytometry for immune cell assessment, and protein analysis via Western blot and qPCR.
• The model group exhibited significantly higher kidney damage scores and increased infiltration of inflammatory macrophages.
• Elevated levels of IL-6, IFNβ, CXCL10, cGAS, and STING mRNA were observed in the model group compared to controls.
• Aloperine treatment reduced kidney damage scores, macrophage infiltration, and inflammatory mediator expression compared to the model group.