Higher cholesterol-years score independently predicted the development of senile degenerative aortic stenosis in older patients with heterozygous familial hypercholesterolemia.
Observational (n=96)
No
Higher cumulative cholesterol burden, measured by cholesterol-years score, is independently associated with the development of degenerative aortic stenosis in older patients with heterozygous familial hypercholesterolemia.
p-value: p=0.037
We retrospectively evaluated the frequency and identified the factors associated with the development of aortic stenosis (AS) in 96 patients with heterozygous familial hypercholesterolemia (FH). The frequency of AS was 31% (4/13) and that of critical stenosis was 15% (2/13) in older patients over the age of 70 years. All 4 patients with AS were female aged more than 70 years who were diagnosed with FH when aged more than 60 years. There were no significant differences in conventional coronary risk factors; however, the age at cardiac catheterization, age at diagnosis of FH and the cholesterol-years score (CYS) with AS were significantly higher than those without AS (p=0.006, p=0.017, p=0.021, respectively). In multiple regression analysis, CYS was a significant independent predictor for the development of AS (p=0.037) in 13 older patients over the age of 70 years. These results suggest that physicians should be aware that AS needs attention in older patients with heterozygous FH, especially women who have been diagnosed late in life and those who have been inadequately treated.
Nozue et al. (Thu,) conducted a observational in Heterozygous familial hypercholesterolemia (n=96). Cholesterol-years score (CYS) vs. Patients without aortic stenosis was evaluated on Development of aortic stenosis (p=0.037). Higher cholesterol-years score independently predicted the development of senile degenerative aortic stenosis in older patients with heterozygous familial hypercholesterolemia.