Clinical parameters affecting the course of amyotrophic lateral sclerosis: a longitudinal analysis of the Greek registry for amyotrophic lateral sclerosis (ALS-GR)

Key Points

• This research aims to understand how various clinical parameters impact survival and functional decline in amyotrophic lateral sclerosis (ALS).
• Analyzed data from the Greek ALS registry (ALS-GR) over time.
• Evaluated associations between clinical parameters and survival rates.
• Assessed functional decline using ALSFRS-R scores.
• Lower ALSFRS-R scores at baseline correlate with shorter survival.
• Older age at diagnosis is linked to decreased survival rates.
• Factors like dysphagia, depression, and pain contribute to faster functional decline.