73P Enhancing CAR T cell therapy through the epigenetic reprogramming of memory gene transcriptional circuits

Key Points

• The research aims to investigate how epigenetic reprogramming can enhance CAR T cell therapy and its effects on patient outcomes.
• Utilized Kaplan-Meier survival curves to analyze overall survival (OS) benefits.
• Examined variations of cytokines IL-4 and IL-12p70 as biomarkers.
• Conducted statistical analyses to identify significance in patient responses.
• Patients with positive IL-4 or IL-12p70 variations showed significantly improved mOS (31.4 vs 11.7 months, p<0.001).
• Identified cytokine variations as important non-invasive biomarkers for predicting treatment response.