173P Prospective, observational study evaluating the feasibility of a systematic and standardized assessment of supportive care needs in patients with advanced solid cancer at the inclusion in early phase clinical trials at the Institut Curie (IC)

grade 2 vulvovaginitis.A statistically significant association was observed between obesity and the incidence of acute radiodermatitis (p<0.001),enteritis (p<0.0001), and cystitis (p 0.006).Subgroup analysis of obese patients revealed a significant increase in acute enteritis in cases of lymph node dissection (p 0.049), associated chemotherapy (p 0.005), and in the presence of other comorbidities (p 0.003).Acute radiodermatitis was also significantly increased in cases where chemotherapy was added (p 0.0002).Age, tumor stage, and dose received were not significantly associated with toxicities. Conclusions:The results of our study highlight the negative impact of obesity on tolerance to pelvic radiotherapy in these patients, which is consistent with the literature.