Modeling small vessel disease burden and vascular dementia likelihood from NACC data

Key Points

• The aim is to develop a framework for modeling the impact of cerebrovascular health on dementia diagnoses.
• Utilized data from the National Alzheimer Coordinating Center (NACC)
• Developed a reproducible modeling framework
• Analyzed the relationship between cerebrovascular pathology and dementia outcomes
• Established a connection between small vessel disease and vascular dementia likelihood
• Demonstrated the framework's utility in understanding mixed dementias
• Provided insights into the burden of cerebrovascular conditions on cognitive health