Abstract Breast cancer remains a leading cause of cancer-related mortality, with brain metastasis contributing significantly to poor outcomes. Triple-negative breast cancer (TNBC) exhibits aggressive behavior, a high incidence of brain metastasis, and limited therapeutic options, underscoring the urgent need for novel strategies targeting brain metastatic vulnerabilities. We recently established an in vivo brain metastasis model using an optimized intracarotid injection method and integrated bioinformatics to identify drivers of metastatic colonization. TUBB2B, a β-tubulin isoform involved in axon guidance during neural development, was identified as a novel TNBC gene promoting brain metastatic outgrowth (He et. al. J Exp Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 3094.
He et al. (Fri,) studied this question.