Does exercise training reduce sympathetic nerve activity and oxidative stress in stroke-prone spontaneously hypertensive rats?
Exercise training reduces sympathetic nerve activity in hypertensive rats by decreasing oxidative stress via AT1R blockade in the rostral ventrolateral medulla.
Exercise training normalizes sympathetic outflow in hypertension and chronic heart failure. The aim of this study was to determine whether the exercise training inhibits sympathetic nerve activity (SNA) via reduction of oxidative stress through blocked angiotensin II type 1 receptor (AT1R) in rostral ventrolateral medulla (RVLM). We divided stroke-prone spontaneously hypertensive rats (SHRSP) into SHRSP with exercised training (SHRSP-EX) and control (SHRSP-C). SNA and oxidative stress in the RVLM were significantly lower in SHRSP-EX than in SHRSP-C. These results suggest that exercise training inhibits SNA via reduction of oxidative stress through blocked AT1R in the RVLM of hypertension.
Kishi et al. (Fri,) studied this question.
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