Does the introduction of inactivated poliovirus vaccine reduce the global burden of Vaccine-Associated Paralytic Poliomyelitis compared to oral poliovirus vaccine?
Universal introduction of inactivated poliovirus vaccine is estimated to decrease the global VAPP burden by 80%-90%.
Because many high-income countries have replaced OPV with inactivated poliovirus vaccine, the VAPP burden is concentrated in lower-income countries. The planned universal introduction of inactivated poliovirus vaccine is likely to substantially decrease the global VAPP burden by 80%-90%.
Platt et al. (Tue,) studied this question.