Does bivalirudin using adult dosing provide safe and predictable anticoagulation in pediatric patients undergoing intravascular procedures for congenital heart disease?
Bivalirudin using adult dosing is a safe and predictable anticoagulant for pediatric patients undergoing catheterization for congenital heart disease.
PK/PD response of bivalirudin in the pediatric population is predictable and behaves in a manner similar to that in adults. Using adult dosing, bivalirudin safely provided the expected anticoagulant effect in the pediatric population undergoing intravascular procedures for congenital heart disease.
Forbes et al. (Tue,) studied this question.