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November 18, 2014Circulation1,062 citations

Regional Variation in Patients and Outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) Trial

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MPMarc A. PfefferBCBrian ClaggettSASusan F. Assmann

Key Points

  • The aim is to examine regional variations in patient outcomes from the treatment of heart failure with preserved cardiac function using aldosterone antagonists.
  • Randomized trial with participants identified through clinical registry NCT00094302.
  • Focus on treatment with aldosterone antagonists for heart failure patients with preserved cardiac function.
  • Evaluation of various regional outcomes among participants.
  • Regional variations in patient outcomes were observed across different locations.
  • Significant differences in treatment response among subgroups were noted.
  • Aldosterone antagonists showed varying effectiveness depending on regional factors.

Abstract

http://www.clinicaltrials.gov. Unique identifier: NCT00094302.

Expert Takes1 quote

“The community had hoped that the trial would provide a more-conclusive answer about the clinical efficacy of spironolactone in this population after positive signals were seen in the Americas cohort of TOPCAT.”

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Cite This Study

Pfeffer et al. (2014) studied this question.

synapsesocial.com/papers/69d575396e4506aa303c1461https://doi.org/10.1161/circulationaha.114.013255
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