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“The community had hoped that the trial would provide a more-conclusive answer about the clinical efficacy of spironolactone in this population after positive signals were seen in the Americas cohort of TOPCAT.”
Randomized trial investigates outcomes of aldosterone antagonists in heart failure patients, suggesting regional differences in treatment effectiveness.
http://www.clinicaltrials.gov. Unique identifier: NCT00094302.
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Pfeffer et al. (2014) studied this question.
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