Why the study?
Does spironolactone affect renal function and subsequent mortality compared to placebo in the TOPCAT trial?
Does spironolactone affect renal function and subsequent mortality compared to placebo in the TOPCAT trial?
Although spironolactone increases the incidence of renal function deterioration, it is associated with lower mortality following creatinine increases compared to placebo.
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Marco Metra (2017) studied this question.
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