Key result
Cardiomyopathy-related ventricular arrhythmia mortality falls ~4% annually from 1999 to 2024.
Why the study?
A national longitudinal study examining mortality trends in patients with ventricular arrhythmias and cardiomyopathy was lacking.
Observational (n=81,204)
Effect estimate: AAPC -3.55% (95% CI -3.69 to -3.41)
Absolute Event Rate: 1.01% vs 2.54%
p-value: p=< 0.000001
While overall U.S. mortality associated with ventricular arrhythmias and cardiomyopathy has declined substantially over the past 25 years, significant disparities persist among men, Non-Hispanic Black patients, and those residing in the West and Midwest.
BACKGROUND: Ventricular Arrhythmias (VA) associated with Cardiomyopathy (CM) continues to be the major cause of death. However, a national longitudinal study examining mortality trends from these conditions is still lacking. This study assessed mortality trends due to these conditions among U.S. adults aged ≥ 25 years from 1999 to 2024. METHODS: An observational analysis of U.S. mortalities due to VA in patients with CM (ICD-10 I47.2, I49.0 and I25.5, I42 respectively), was conducted using CDC WONDER. Adjusted Mortality Rates (AAMR) per 100,000 calculated and trends were assessed by calculating Average and Annual Percent Change (AAPC, APC), using joinpoint regression stratified by year, sex, race, and region. RESULTS: From 1999 to 2024, 81,204 VA with CM-related deaths occurred with the overall AAMR declined from 2.54 in 1999 to 1.01 in 2024 (AAPC: -3.55%; p < 0.000001). AAMRs decreased from 1999 to 2007 (APC: -7.93), remained stable till 2022 (APC: -0.66), and dropped by 2024 (APC: -6.87). Men exhibited greater AAMRs (2.42) than women (0.68). Racially, the AAMRs were most pronounced in Non-Hispanic (NH) Blacks (1.97), followed by NH Whites (1.42), whereas Hispanics and NH Others experienced similar AAMRs of 0.97. Geographically, Delaware and the Western regions experienced the highest rates of mortality (2.2 and 1.53, respectively). Urban areas had higher AAMRs than rural settings (1.45 vs. 1.4) CONCLUSION: Although VA-CM mortality has declined over the past two decades, differences by race, sex, and geography remain, underscoring the need for targeted healthcare strategies.
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Pervaiz et al. (2026) conducted an observational in Ventricular Arrhythmias with Cardiomyopathy (n=81,204). Time period (1999-2024) was evaluated on Age-Adjusted Mortality Rate (AAMR) per 100,000 (AAPC -3.55%, 95% CI -3.69 to -3.41, p=< 0.000001). The overall age-adjusted mortality rate for ventricular arrhythmias with cardiomyopathy in U.S. adults declined from 2.54 per 100,000 in 1999 to 1.01 per 100,000 in 2024 (AAPC -3.55%).
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