Key result
Arrhythmia-related age-adjusted mortality in the U.S. increased from 111.4 per 100,000 in 1999 to 137.3 per 100,000 in 2023, peaking in 2021 during the COVID-19 pandemic.
Why the study?
Arrhythmias are a significant cause of cardiovascular mortality in the US, but long-term trends and disparities across sex, race, geography, and urbanization required examination.
Population
5,050,271 arrhythmia-related deaths among US adults aged ≥ 35 years
Comparison
Trends stratified by sex, race/ethnicity, state, region, and urbanization
Design
Retrospective database analysis using Joinpoint regression
Follow-up
25 years (1999 to 2023)
Authors
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Rising arrhythmia mortality supports surveillance; leaves open drivers of the pandemic peak and disparities.
Observational (n=5,050,271)
Absolute Event Rate: 137.3% vs 111.4%
Arrhythmia-related mortality in the U.S. has increased over the past 25 years, peaking during the COVID-19 pandemic, with persistent disparities across sex, race, and geographic regions.
Azeem et al. (2025) conducted an observational in Arrhythmia-related mortality (n=5,050,271). Time period (1999-2023) vs. 1999 baseline was evaluated on Age-adjusted mortality rate (AAMR) per 100,000. Arrhythmia-related age-adjusted mortality in the U.S. increased from 111.4 per 100,000 in 1999 to 137.3 per 100,000 in 2023, peaking in 2021 during the COVID-19 pandemic.
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