F-31 | Where Adults with Arrythmias Die: Insights From the CDC-WONDER Database

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Arrhythmia-related mortality in obese adults (n=108173). Primary outcome: Average annual percent changes (AAPC) in age-adjusted mortality rate (AAMR) (AAPC +24.2%, p=<0.001).

Q: What does this research mean for the field?

Arrhythmia-related mortality among obese adults surged significantly from 2018 to 2021 before declining from 2021 to 2024, with persistent demographic and geographic disparities, particularly in Non-Hispanic Black populations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Muhammad Hasan; Muhammad Hammad Chola; Muhammad Junaid Razzak; Syeda Javaria Batool; Mariam Bahzad; Muhammad Abdullah Naveed; Sadiq Murtaza Sheriff; Hamna Ali; Ahila Ali; Nosheen Pervaiz; Hamza Ali; Bhavya Koganti; Himaja Dutt Chigurupati; Sivaram Neppala

doi:10.1016/j.jscai.2026.105143

April 1, 2026Journal of the Society for Cardiovascular Angiography & InterventionsOpen Access

F-31 | Where Adults with Arrythmias Die: Insights From the CDC-WONDER Database

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Key Points

To analyze arrhythmia-related mortality trends among adults in the U.S. from 1999 to 2024.
Utilized CDC-WONDER database to evaluate mortality data for 108,173 decedents.
Stratified findings by factors such as sex, race, region, and urbanization.
Calculated average annual percent change (AAPC) in arrhythmia-related mortality rates.
Arrhythmia-related mortality rates increased by 5.8% annually from 1999-2018 (p < 0.001).
Significant rise from 2018-2021 (+24.2%, p < 0.001) followed by a decline in 2021-2024 (-8.6%, p < 0.001).
Notable disparities in mortality observed, particularly among NH Black (2.1) and Hispanic adults (+31.6%, p < 0.001) during peak years.

Study Design

Type

Observational (n=108,173)

Structured PICO

P

Population

108,173 decedents (adults with arrhythmias, noted as obese adults in conclusion) from the U.S. CDC-WONDER Database, 54.8% male.

O

Outcome

Arrhythmia-related mortality (Age-Adjusted Mortality Rate) and location of deathhard clinical

Main Result

Effect estimate: AAPC +24.2%

p-value: p=<0.001

Implication

Arrhythmia-related mortality in the US surged between 2018 and 2021, with significant demographic and regional disparities highlighting the need for targeted interventions in high-risk groups.

Discussion

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Cite This Study

Hasan et al. (2026) conducted an observational in Arrhythmia-related mortality in obese adults (n=108,173).

synapsesocial.com/papers/69edab424a46254e215b3531 https://doi.org/10.1016/j.jscai.2026.105143

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F-31 | Where Adults with Arrythmias Die: Insights From the CDC-WONDER Database

Key Points

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

F-31 | Where Adults with Arrythmias Die: Insights From the CDC-WONDER Database

Key Points

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

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