Baseline Distribution of Participants With Depression and Impaired Quality of Life in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial
Population
3400 patients with heart failure with preserved ejection fraction enrolled in the TOPCAT trial
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
May warrant depression screening in HFpEF; leaves open whether targeting associated factors improves outcomes.
Structured PICO
P
Population
3400 patients with heart failure with preserved ejection fraction enrolled in the TOPCAT trial (3400 completed KCCQ, 3395 completed EQ-5D VAS, and 1431 in US and Canada completed PHQ-9)
O
Outcome
Baseline characteristics related to impaired quality of life (QOL) and depression, predictors of poor QOL and depression, and correlation between QOL and depressionpatient reported
In patients with HFpEF, younger age, higher NYHA class, comorbid angina, lower activity levels, and use of hypoglycemic agents are associated with impaired quality of life and depression.
Cite This Study
Hamo et al. (2015) studied this question.