February 23, 2022Open Access
Polypharmacy occurrence and the related risk of premature death among older adults in Denmark: A nationwide register-based cohort study
Structured PICO
Does polypharmacy increase the risk of premature death in older adults?
P
Population
older adults in Denmark
I
Intervention
polypharmacy
O
Outcome
premature deathhard clinical
Polypharmacy is associated with a significantly increased mortality risk among older adults, highlighting the need to evaluate medication appropriateness.
Abstract
A considerable proportion of older adults in Denmark were exposed to polypharmacy dependent on health status, socio-economic status, and societal factors. The associated three- to four-fold mortality risk indicate a need for further exploration of the appropriateness of polypharmacy among older adults.