Key points are not available for this paper at this time.
reaction: see text Perturbing influences, such as strain and the presence of heteroatoms, complicate the evaluation of aromatic stabilization energies (ASE). These complications are overcome easily by employing the "isomerization method". This is based on the differences (ISE) between total energies computed for only two species: a methyl derivative of the aromatic system and its nonaromatic exocyclic methylene isomer. The ISEs of benzene, pyridine, and naphthalene as well as the strained 5paracyclophane, methano10annulene, and octadehydro14annulene are evaluated.
Schleyer et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: