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ADVERTISEMENT RETURN TO ISSUECurrent Topics/Persp...Current Topics/PerspectivesNEXTChemical Basis for Enzyme CatalysisThomas C. Bruice and Stephen J. BenkovicView Author Information Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, and Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802 Cite this: Biochemistry 2000, 39, 21, 6267–6274Publication Date (Web):May 5, 2000Publication History Received16 February 2000Revised12 April 2000Published online5 May 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/bi0003689https://doi.org/10.1021/bi0003689review-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views4418Altmetric-Citations243LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Conformation,Molecular structure,Peptides and proteins,Transition states Get e-Alerts
Bruice et al. (Mon,) studied this question.