February 1, 2000

Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With 11CWAY-100635

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Abstract

Major depressive disorder is associated with a widespread reduction in 5-HT1A receptor binding. This reduced 5-HT1A receptor binding was not changed by selective serotonin reuptake inhibitor treatment.

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Cite This Study

Sargent et al. (Tue,) studied this question.

synapsesocial.com/papers/69d78128aa68b335b4f31d35 https://doi.org/https://doi.org/10.1001/archpsyc.57.2.174

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Neuroanatomical circuits in depression: implications for treatment mechanisms.1992 · 227 citations
2Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics1993 · 345 citations
3Hippocampal atrophy in recurrent major depression.1996 · 1,923 citations
4Co-Planar Stereotaxic Atlas of the Human Brain1988 · 11,681 citations
5Remotely-controlled production of the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635, via 11C-carboxylation of an immobilized Grignard reagent1996 · 122 citations

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