May 30, 2014Open Access

Anti-Fibrotic Actions of Interleukin-10 against Hypertrophic Scarring by Activation of PI3K/AKT and STAT3 Signaling Pathways in Scar-Forming Fibroblasts

JSJihong ShiChinese Academy of Medical Sciences & Peking Union Medical College JLJun LiUniversity of Notre Dame HGHao GuanXi'an Medical University

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Abstract

IL-10 apparently inhibits fibrosis by activating AKT and STAT3 phosphorylation downstream of the IL-10 receptor, and by facilitating crosstalk between the PI3K/AKT and STAT3 signal transduction pathways.

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