May 22, 2025Open Access

Analyzing the relationship of RNA and DNA methylation with gene expression

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Abstract

RNA methylation has a stronger effect on gene expression than does DNA methylation within gene bodies and promoters. DNA and RNA methylation in gene-bodies has a greater impact on gene expression than those in promoters. These findings deepen comprehension of the dynamics and complex relationships among the epigenome, epitranscriptome, and transcriptome, offering fresh insights for advancing epigenetics research.

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Xie et al. (Thu,) studied this question.

synapsesocial.com/papers/69d819e45c3030ff03d194e9 https://doi.org/https://doi.org/10.1186/s13059-025-03617-3

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