September 1, 2000

Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock

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Abstract

Focal apoptosis of intestinal epithelial and lymphoid tissues occurs extremely rapidly after injury. Apoptotic loss of intestinal epithelial cells may compromise bowel wall integrity and be a mechanism for bacterial or endotoxin translocation into the systemic circulation. Apoptosis of lymphocytes may impair immunologic defenses and predispose to infection.

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Cite This Study

Hotchkiss et al. (Fri,) studied this question.

synapsesocial.com/papers/69d8396e8c03fbaff8bee342 https://doi.org/https://doi.org/10.1097/00003246-200009000-00016

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1LYMPHOCYTE SUBSET RESPONSES TO TRAUMA AND SEPSIS1993 · 117 citations
2Major Injury Induces Increased Production of Interleukin-10 by Cells of the Immune System With a Negative Impact on Resistance to Infection1997 · 216 citations
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4Importance of apoptosis in the histopathology of drug related lesions in the large intestine.1993 · 205 citations
5EFFECT OF MESENTERIC ISCHEMIA AND REPERFUSION OR HEMORRHAGIC SHOCK ON INTESTINAL MUCOSAL PERMEABILITY AND ATP CONTENT IN RATS1999 · 112 citations

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