October 15, 2003Open Access

Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

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Abstract

Autoantibodies are typically present many years before the diagnosis of SLE. Furthermore, the appearance of autoantibodies in patients with SLE tends to follow a predictable course, with a progressive accumulation of specific autoantibodies before the onset of SLE, while patients are still asymptomatic.

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Arbuckle et al. (Wed,) studied this question.

synapsesocial.com/papers/69d84a25d2f7327e70ae2b5b https://doi.org/https://doi.org/10.1056/nejmoa021933

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