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Research Paper | Synapse

April 10, 2026Open Access

Low blood zinc exacerbates minimal hepatic encephalopathy via altered functional brain activity

Key Points

The study aims to understand how low blood zinc levels contribute to cognitive impairment in minimal hepatic encephalopathy.
Assessment of blood zinc levels in patients with minimal hepatic encephalopathy.
Analysis of neural activity in specific brain regions.
Comparison of brain activity patterns with cognitive function.
Lower blood zinc levels correlate with altered neural activity in the angular gyrus, precuneus, and fusiform gyrus.
Altered brain activity suggests a neural basis for cognitive impairment associated with minimal hepatic encephalopathy.

Abstract

Low blood zinc levels in patients with MHE are associated with altered neural activity in the bilateral angular gyrus, precuneus, and bilateral fusiform gyrus, representing a neural basis for cognitive impairment in MHE.

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Journals

Digestive and Liver Disease

Institutions

Fujian Medical University

Union Hospital

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Cite This Study

Jiang et al. (Wed,) studied this question.

synapsesocial.com/papers/69d892886c1944d70ce03ee4 https://doi.org/https://doi.org/10.1016/j.dld.2026.03.012