What question did this study set out to answer?

The study examines the risks of pancreatitis during the use of methimazole and propylthiouracil in treating Graves' disease.

April 10, 2026Open Access

Drug cross-reactivity between methimazole and propylthiouracil causing recurrent pancreatitis in thyroid storm

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Key Points

The study examines the risks of pancreatitis during the use of methimazole and propylthiouracil in treating Graves' disease.
Assessment of adverse effects related to methimazole (MMI) and propylthiouracil (PTU) treatment.
Consideration of switching therapies and alternative treatments such as radioactive iodine or surgical options.
Monitoring of IgG4 concentration as an inflammatory marker.
Identified potential for cross-reactivity between MMI and PTU leading to pancreatitis.
Noted that IgG4 levels may increase during adverse drug reactions.
Emphasized caution when switching between these medications.

Abstract

If abdominal pain, nausea, or vomiting occurs during drug therapy for Graves' disease, drug-induced pancreatitis should be considered in the differential diagnosis. If pancreatitis develops during treatment with MMI, switching to PTU should be approached with caution due to the potential for cross-reactivity - and vice versa. In the event that MMI or PTU results in adverse effects, alternative therapeutic modalities should be considered, including radioactive iodine (131I) therapy or surgical interventions. These considerations should be informed by the concomitant increase in IgG4 concentration.

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Discussion

Cite this study

Yamazaki et al. (Wed,) studied this question.

synapsesocial.com/papers/69d893406c1944d70ce043f0 — DOI: https://doi.org/10.1530/edm-25-0135

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Authors

Yuriko Yamazaki

Social Insurance Saitama Chuo Hospital

Junichiro Adachi

Social Insurance Saitama Chuo Hospital

Yurika Ishihara

Social Insurance Saitama Chuo Hospital

Journals

Endocrinology Diabetes and Metabolism Case Reports

Actions

Institutions

Saitama Medical University

Social Insurance Saitama Chuo Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Drug cross-reactivity between methimazole and propylthiouracil causing recurrent pancreatitis in thyroid storm

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

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Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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