Zinc-chelated cuttlefish ink melanin nanoparticles complexed sprayable chitosan-based hydrogel to promote infected wounds healing

Key Points

• To evaluate the efficacy of a zinc-chelated cuttlefish ink melanin nanoparticle complex in healing infected wounds using a chitosan-based hydrogel.
• Developed a sprayable hydrogel formulation using chitosan and zinc-chelated cuttlefish ink melanin nanoparticles.
• Assessed healing effects on infected wound models using appropriate controls.
• Analyzed biological responses through histological evaluations and healing rate assessments.
• The hydrogel formulation significantly enhanced wound healing compared to controls.
• Histological analysis showed improved tissue regeneration and reduced infection signs in treated wounds.
• Healing rates were notably higher in model subjects treated with the zinc-chelated formulation.