Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma

Key Points

• This research aims to explore how childhood trauma affects working memory through frontoparietal network flexibility in schizophrenia.
• Examined the relationship between childhood trauma and cognitive performance in schizophrenia
• Assessed frontoparietal network flexibility using neuroimaging techniques
• Analyzed symptom burden to understand its impact on cognition
• Frontoparietal network flexibility mediates the effect of childhood trauma on working memory
• Higher trauma exposure correlates with increased cognitive dysfunction
• Symptom burden influences cognitive performance in patients with schizophrenia