Cerebrospinal Fluid IgG4 as a Key Diagnostic Clue in IgG4‐Related Spinal Pachymeningitis With Normal Serum Levels

Key Points

• To evaluate the role of cerebrospinal fluid IgG4 levels in diagnosing IgG4-related spinal pachymeningitis.
• Analyzed cerebrospinal fluid samples from patients with suspected spinal pachymeningitis.
• Compared IgG4 levels in cerebrospinal fluid to serum levels.
• Identified diagnostic markers for the condition.
• Elevated IgG4 levels were found in cerebrospinal fluid despite normal serum levels.
• The study highlights cerebrospinal fluid IgG4 as a potential diagnostic marker.
• Findings suggest a distinct pathophysiological role for IgG4 in spinal pachymeningitis.